Any mammal can get rabies. However, the chance of rabies in an opossum is extremely rare. This may have something to do with the opossum's low body temperature (94-97° F) making it difficult for the virus to survive in an opossum's body.

Opossums have more teeth than any other North American mammal, a total of 50 in all.

Opossums are omnivores and eat a wide range of plants and animals. Their normal diet consists of carrion, rodents, insects, snails, slugs, birds, eggs, frogs, plants, fruits and grains. They also eat human food, table scraps, dog food and cat food. Since they groom themselves fastidiously, if they find a tick, they will lick it off and swallow it. It is estimated that a single opossum might kill up to 5,000 ticks in a season.

Crash and Eddie are twin brother opossums who adopt Ellie (a wooly mammoth) and teach her to hang by her tail from a tree branch while she sleeps.